Challenges in reducing group B Streptococcus disease in African settings

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Challenges in reducing group B Streptococcus disease in African settings

Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis in high-income settings and is associated with high rates of neonatal mortality and morbidity. There is now increasing evidence to suggest that there is a high GBS disease burden in resource-limited countries, and it is therefore critically important to identify suitable and practical preventive strategies. In Euro...

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Burden of Invasive Group B Streptococcus Disease and Early Neurological Sequelae in South African Infants

INTRODUCTION Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis. We aimed to evaluate the burden of invasive early-onset (0-6 days of life, EOD) and late-onset (7-89 days, LOD) GBS disease and subsequent neurological sequelae in infants from a setting with a high prevalence (29.5%) of HIV among pregnant women. METHODS A case-control study was undertaken at three ...

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Frequency and Drug Resistance of Group B Streptococcus in Pregnant Women in Markazi Province, Iran

Abstract Background and Objective: Group B streptococcus is one of the agents leading to infantile blood infection and meningitis as well as aggressive infections in pregnant women. The vast use of antibiotics in order to prevent from the diseases caused by this bacterium has led to some concerns about the emergence of drug resistance in Group B streptococcus. Thus, we aimed to investigate Grou...

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Immune Response to Invasive Group B Streptococcus Disease in Adults

Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, ident...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2016

ISSN: 0003-9888,1468-2044

DOI: 10.1136/archdischild-2016-311419